Can gestational exercise have a positive effect on cognitive functions resulting from brain injury? A rat study

Aim: The effects of gestational exercise on potential pathological conditions is not known yet.  Therefore, in the present study, it was aimed to evaluate the effects of forced running exercise on LPS-induced brain damage in pregnant rats. Method: Pregnant females in the experimental group were forced to exercise 30 min daily for five days a week. Lipopolysaccharide (LPS) induced brain injury model was created by administering 500 µg/kg body weight of LPS on gestational days 18 and 19.   To evaluate injury histopathologically, brain tissues were fixed at the postnatal day seven through transcardial perfusion (n=4 pups/group). When the remaining pups reached 30-day of age, Morris water maze test (MWM) was performed to assess memory and learning, open filed (OP) and elevated plus maze (EPM) for testing anxiety, and Porsolt test (PT) for evaluating depression. The groups were defined as brain injury group (BI, n=13) and exercise+brain injury group (E+BI, n=7).  Results: The results obtained from MWM test indicated that animals found the platform in a shorter duration and distance at the day five compared to the day three. However, there was no significant difference between the groups. No significant difference was found in OP test regarding the distance traveled, time spent at the margins, movement at the center and the time spent as immobile. However, in the EPM test, the offspring at the BI group displayed higher mobility and increased number of entry to the open arms compared to the E+BI groups (p=0.01).  There was no significant difference regarding mobility duration and total distance traveled in the PT test. Conclusion: In the present study, we tested the impact of gestational exercise using the brain injury model. The results of the EPM test suggests that the gestational exercise can suppress the stress factors in the pregnant females with brain injury leading to the prevention of hyperactivity-induced negative learning behavior

Reasons why Hypertensive Patients Admission to Emergency Services and their Chronic Illness Care Management

The study sample was composed of 200 individuals with hypertension who were admitted to the emergency department of a government hospital. Of the participants, 36.5% presented to the emergency department. Of the participants, those who were older, who had a low education level, who consumed salt without restriction, coffee drinkers, who were not on a diet and who did not receive health education obtained lower scores from the Patient Assessment of Chronic Illness Care scale. Effective discharge planning from hospital to home, home visits and counselling provided by primary health care departments will contribute to a reduction in emergency admissions and to successful chronic disease management.</p

Synthesis and Biological Evaluation of Some Succinimide Hybrid Molecules

WOS: 000520225900015In this study, a new series of succinimide hybrid molecules containing isothiocyanate, coumarin, isatin, and furan moieties was synthesized and screened for alpha-glucosidase and antioxidant activities. Preliminary results revealed that all molecules showed good alpha-glucosidase inhibition effectiveness. Antioxidant activities of the hybrid molecules were determined using cupric reducing antioxidant capacity (CUPRAC) and ferric reducing antioxidant power (FRAP) assays. Also, the radical scavenging activities of the synthesized compounds were assayed by using the results showed that all compounds exhibited moderated to high scavenging activity

Synthesis and Antioxidant Evaluation of Some Novel Benzimidazole Derivatives Containing a Triazole Nucleus

WOS: 000395673500010Various benzimidazole compounds containing a triazole nucleus were synthesized and screened for their antioxidant activies. the structures of newly synthesized compounds were characterized by H-1 NMR, C-13 NMR and elemental analysis data. Antioxidant features of the synthesized compounds were investigated by different processes such as 2,2-diphenyl picryl hydrazyl (DPPH), 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) and CUPric reducing antioxidant capacity (CUPRAC) methods. Significant antioxidant activity was achieved by some of the synthesized compounds demonstrated as much activity as standards (AA and BHT). Correlation analysis between the CUPRAC antioxidant and ABTS radical scavenging assays revealed positive correlation (R-2=0.926), indicating differing antioxidant activities based on the reaction mechanism.Recep Tayyip Erdogan University Scientific Research Project UnitRecep Tayyip Erdogan University [2014.102.02.05]; Recep Tayyip Erdogan UniversityRecep Tayyip Erdogan UniversityThe authors report no conflicts of interest. This work was supported by Recep Tayyip Erdogan University Scientific Research Project Unit (BAP) under project number: 2014.102.02.05. Authors thank to Recep Tayyip Erdogan University for this support

Synthesis of some novel quinazolin-4(3H)-one hybrid molecules as potent urease inhibitors

emirik, mustafa/0000-0001-9489-9093WOS: 000451876200004PubMed: 30375666A new series of quinazolinone hybrid molecules containing coumarin, furan, 1,2,4-triazole and 1,2,4-thiadiazole rings was designed, synthesized, and screened for their urease inhibition activities. All newly synthesized compounds showed outstanding urease inhibitory potentials with IC50 values ranging between 1.26 +/- 0.07 and 7.35 +/- 0.31 mu g/mL. Among the series, coumarin derivatives (10a-d) exhibited the best inhibitory effect against urease in the range of IC50 = 1.26 +/- 0.07 to 1.82 +/- 0.10 mu g/mL, when compared to standard urease inhibitors such as acetohydroxamic acid and thiourea (IC50 = 21.05 +/- 0.96 and 15.08 +/- 0.71 mu g/mL, respectively). Molecular docking studies were also performed to analyze the binding mode of compound 10b, and supported the experimental results.Recep Tayyip Erdogan University Scientific Research Project Unit (BAP)Recep Tayyip Erdogan University [FBA-2017-720]; Recep Tayyip Erdogan UniversityRecep Tayyip Erdogan UniversityThis work was supported by Recep Tayyip Erdogan University Scientific Research Project Unit (BAP) under project number of FBA-2017-720. Authors thank Recep Tayyip Erdogan University for this support

Synthesis of Some New Benzimidazole Derivatives with their Antioxidant Activities

WOS: 000351780600001In this paper, some benzimidazole derivatives containing salicyl, oxadiazole, thiosemicarbazide and 1, 2, 4-triazole moieties have been synthesized and screened their antioxidant activities screened. Antioxidant activities of the synthesized compounds were tested with DPPH and ABTS(center dot+) radical cation decolorization assays. Compounds 4b, 6a, 6b, 7a and 7b showed very good scavenging activity

Synthesis and antioxidant activities of some new triheterocyclic compounds containing benzimidazole, thiophene, and 1,2,4-triazole rings

WOS: 000359815200014PubMed: 25198894Various triheterocyclic compounds containing benzimidazole, thiophene, and 1,2,4-triazole rings (3-6) were synthesized and screened for their antioxidant activities. the structures of the synthesized compounds (2-6) were judged by H-1 NMR, C-13 NMR, elemental analysis, and LC-MS spectral data. Antioxidant activities of the synthesized compounds (2-6) were determined with CUPric Reducing Antioxidant Capacity (CUPRAC), ABTS (2,2-azinobis(3-ethylbenzothiazoline-6-sulfonic acid)/persulfate, and DPPH (1,1-diphenyl-2-picrylhydrazyl) assays. Most of the compounds showed a significant antioxidant activity and especially, compound 5c showed very good SC50 value for DPPH method and compound 5h exhibited very high scavenging activity to ABTS method